References

Below are selected research papers that are useful to understanding how SAA detection of misfolded aggregates of ɑ-Synuclein is the essential piece of the neurodegenerative disease diagnostic puzzle.

Assessment of heterogeneity among participants in the Parkinson’s Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study.

A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research.

A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria.

Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort.

Seed amplification assay results illustrate discrepancy in Parkinson’s disease clinical diagnostic accuracy and error rates.

α-Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α-Synuclein in the Context of Co-Pathology and Non-LBD Diagnoses.

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.

10.

Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies.

11.

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.

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Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.

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Structures of α-synuclein filaments from human brains with Lewy pathology.

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Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.

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Analysis of Protein Conformational Strains—A Key for New Diagnostic Methods of Human Diseases.

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Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.

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Investigating alpha-synuclein co-pathology in Alzheimer's disease by means of cerebrospinal fluid alpha-synuclein seed amplification assay.

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