Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study | November 21, 2024 | The Lancet Neurology | Scientific paper | | scientific-paper |
Association of CSF α-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer’s Disease Neuroimaging Initiative study | October 20, 2024 | Alzheimer's & Dementia | Scientific paper | | scientific-paper |
α-Synuclein seed amplification technology for Parkinson’s disease and related synucleinopathies | July 1, 2024 | Trends in Biotechnology | Literature review | | literature-review |
α-Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α-Synuclein in the Context of Co-Pathology and Non-LBD Diagnoses | July 29, 2024 | Annals of Neurology | Scientific paper | | scientific-paper |
α-Synuclein seed amplification assay shows potential to unmask pathology and enable biologically-based therapeutic development | June 1, 2023 | Movement Disorders | Position paper | | position-paper |
α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer’s disease late in the disease course and dependent on Lewy pathology burden | April 26, 2024 | Alzheimer's & Dementia | Scientific paper | | scientific-paper |
Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies | April 27, 2024 | Acta Neuropathologica Communications | Scientific paper | | scientific-paper |
Structures of α-synuclein filaments from human brains with Lewy pathology | September 15, 2022 | Nature | Scientific paper | | scientific-paper |
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies | April 7, 2021 | Acta Neuropathologica Communications | Scientific paper | | scientific-paper |
Seed amplification assay results illustrate discrepancy in Parkinson’s disease clinical diagnostic accuracy and error rates | August 17, 2023 | Journal of Neurology | Scientific paper | | scientific-paper |
Revised criteria for diagnosis and staging of Alzheimer’s disease: Alzheimer’s Association Workgroup | June 27, 2024 | Alzheimer's & Dementia | Position paper | | position-paper |
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC | February 9, 2018 | Acta Neuropathologica Communications | Scientific paper | | scientific-paper |
Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer’s disease spectra | March 4, 2024 | Annals of Clinical and Translational Neurology | Scientific paper | | scientific-paper |
Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment | January 25, 2024 | European Journal of Neurology | Scientific paper | | scientific-paper |
Investigating alpha-synuclein co-pathology in Alzheimer’s disease by means of cerebrospinal fluid alpha-synuclein seed amplification assay | February 7, 2024 | Alzheimer's & Dementia | Scientific paper | | scientific-paper |
Investigating alpha-synuclein co-pathology in Alzheimer’s disease by means of cerebrospinal fluid alpha-synuclein seed amplification assay | February 7, 2024 | Alzheimer's & Dementia | Scientific paper | | scientific-paper |
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease | November 6, 2021 | Acta Neuropathologica Communications | Scientific paper | | scientific-paper |
Evaluation of Cerebrospinal Fluid α-Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome | September 20, 2024 | Movement Disorders | Scientific paper | | scientific-paper |
Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy | February 5, 2020 | Nature | Scientific paper | | scientific-paper |
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study | March 1, 2021 | The Lancet Neurology | Scientific paper | | scientific-paper |
CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorders | August 29, 2024 | Neurology | Scientific paper | | scientific-paper |
Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort | March 27, 2024 | Alzheimer's & Dementia | Scientific paper | | scientific-paper |
Associations between misfolded alpha-synuclein aggregates and Alzheimer’s disease pathology in vivo | September 11, 2024 | Alzheimer's & Dementia | Scientific paper | | scientific-paper |
Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies | July 16, 2024 | Neurology | Scientific paper | | scientific-paper |
Assessment of heterogeneity among participants in the Parkinson’s Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study | May 1, 2023 | The Lancet Neurology | Scientific paper | | scientific-paper |
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases | April 17, 2020 | International Journal of Molecular Sciences | Scientific paper | | scientific-paper |
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies | August 28, 2016 | Annals of Clinical and Translational Neurology | Scientific paper | | scientific-paper |
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure | April 30, 2021 | Annals of Neurology | Scientific paper | | scientific-paper |
Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson’s Disease in the DeNovo Parkinson (DeNoPa) Cohort | February 13, 2024 | Movement Disorders | Scientific paper | | scientific-paper |
A cross-sectional study of α-synuclein seed amplification assay in Alzheimer’s disease neuroimaging initiative: Prevalence and associations with Alzheimer’s disease biomarkers and cognitive function | May 21, 2024 | Alzheimer's & Dementia | Scientific paper | | scientific-paper |
A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research | February 1, 2024 | The Lancet Neurology | Literature review | | literature-review |
A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria | February 1, 2024 | The Lancet Neurology | Literature review | | literature-review |
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases | April 17, 2020 | International Journal of Molecular Sciences | Scientific paper | | scientific-paper |