Misfolded α-Synuclein Research Studies

Innovative science. Informative insights.

TitlePublication DatePublicationCategoriesLinkhf:doc_categories
Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort studyNovember 21, 2024The Lancet Neurologyscientific-paper
Association of CSF α-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer’s Disease Neuroimaging Initiative studyOctober 20, 2024Alzheimer's & Dementiascientific-paper
α-Synuclein seed amplification technology for Parkinson’s disease and related synucleinopathiesJuly 1, 2024Trends in Biotechnologyliterature-review
α-Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α-Synuclein in the Context of Co-Pathology and Non-LBD DiagnosesJuly 29, 2024Annals of Neurologyscientific-paper
α-Synuclein seed amplification assay shows potential to unmask pathology and enable biologically-based therapeutic development June 1, 2023Movement Disordersposition-paper
α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer’s disease late in the disease course and dependent on Lewy pathology burdenApril 26, 2024Alzheimer's & Dementiascientific-paper
Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathiesApril 27, 2024Acta Neuropathologica Communicationsscientific-paper
Structures of α-synuclein filaments from human brains with Lewy pathologySeptember 15, 2022Naturescientific-paper
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodiesApril 7, 2021Acta Neuropathologica Communicationsscientific-paper
Seed amplification assay results illustrate discrepancy in Parkinson’s disease clinical diagnostic accuracy and error ratesAugust 17, 2023Journal of Neurologyscientific-paper
Revised criteria for diagnosis and staging of Alzheimer’s disease: Alzheimer’s Association WorkgroupJune 27, 2024Alzheimer's & Dementiaposition-paper
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuICFebruary 9, 2018Acta Neuropathologica Communicationsscientific-paper
Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer’s disease spectraMarch 4, 2024Annals of Clinical and Translational Neurologyscientific-paper
Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatmentJanuary 25, 2024European Journal of Neurologyscientific-paper
Investigating alpha-synuclein co-pathology in Alzheimer’s disease by means of cerebrospinal fluid alpha-synuclein seed amplification assayFebruary 7, 2024Alzheimer's & Dementiascientific-paper
Investigating alpha-synuclein co-pathology in Alzheimer’s disease by means of cerebrospinal fluid alpha-synuclein seed amplification assayFebruary 7, 2024Alzheimer's & Dementiascientific-paper
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s diseaseNovember 6, 2021Acta Neuropathologica Communicationsscientific-paper
Evaluation of Cerebrospinal Fluid α-Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal SyndromeSeptember 20, 2024Movement Disordersscientific-paper
Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophyFebruary 5, 2020Naturescientific-paper
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational studyMarch 1, 2021The Lancet Neurologyscientific-paper
CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian DisordersAugust 29, 2024Neurologyscientific-paper
Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohortMarch 27, 2024Alzheimer's & Dementiascientific-paper
Associations between misfolded alpha-synuclein aggregates and Alzheimer’s disease pathology in vivoSeptember 11, 2024Alzheimer's & Dementiascientific-paper
Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy BodiesJuly 16, 2024Neurologyscientific-paper
Assessment of heterogeneity among participants in the Parkinson’s Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional studyMay 1, 2023The Lancet Neurologyscientific-paper
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human DiseasesApril 17, 2020International Journal of Molecular Sciencesscientific-paper
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathiesAugust 28, 2016Annals of Clinical and Translational Neurologyscientific-paper
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic FailureApril 30, 2021Annals of Neurologyscientific-paper
Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson’s Disease in the DeNovo Parkinson (DeNoPa) CohortFebruary 13, 2024Movement Disordersscientific-paper
A cross-sectional study of α-synuclein seed amplification assay in Alzheimer’s disease neuroimaging initiative: Prevalence and associations with Alzheimer’s disease biomarkers and cognitive functionMay 21, 2024Alzheimer's & Dementiascientific-paper
A biological definition of neuronal α-synuclein disease: towards an integrated staging system for researchFebruary 1, 2024The Lancet Neurologyliterature-review
A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteriaFebruary 1, 2024The Lancet Neurologyliterature-review
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human DiseasesApril 17, 2020International Journal of Molecular Sciencesscientific-paper

Amprion Announces

Our flagship α-synuclein SAA, SYNTap®, is getting a makeover.

Effective September 9, 2024, SYNTap will be 

And stay tuned for the SAAmplify family of panels, coming soon!