ABOUT AMPRION
Who we are
We’re explorers who follow the science where it leads us. We’re experts in neurodegenerative disorders, innovators in medicine, and fervent collaborators.
What we do
Amprion is the global leader in advancing the diagnosis of neurodegenerative disorders through development of seed amplification assays (SAA). Amprion Cofounder, Claudio Soto, PhD, originally developed this methodology and it has been further enhanced and validated by Amprion scientists for clinical use. Amprion helps to accelerate precision medicine for neurodegenerative disorders by helping biopharma partners identify new drug candidates and underlying pathologies.
Why we do it
Diagnosis and treatment of neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Lewy body dementia have historically been focused on identifying and treating symptoms. Symptoms can confound diagnosis, as many of these conditions have symptoms in common. Millions of people have had to forego an accurate diagnosis, instead propelled into a “diagnostic odyssey”—a journey in search of answers that are often not revealed until autopsy. Physicians have been limited in their ability to help patients access effective care for their disease, instead having to do their “best” with limited diagnostic tools. And most of today’s medicines aren’t curative, but simply help manage symptoms.
It’s unlikely that any cure can be discovered without an understanding of each patient’s biology and how that is underlying the pathologies they experience. Through highly sensitive, early detection of misfolded proteins, Amprion is reimagining medicine for progressive neurodegeneration in a variety of CNS diseases. Amprion’s mission is to facilitate the end of Alzheimer’s, Parkinson’s, and other neurodegenerative disorders through early diagnostic testing, which provides the biological insights that inform discovery and give rise to effective treatments.
OUR STORY
2007
INCEPTION
Neuroscientist Claudio Soto teams up with molecular pathologist Dr. Russ Lebovitz to work on detecting prions, aka misfolded proteins, relating to Creutzfeldt-Jakob disease (CJD).
2010
PIVOT
As the threat of CJD (mad cow disease) dissipates, the team pivots, asking: Is there a parallel between misfolded proteins in CJD and neurodegenerative disorders?
2013
AHA MOMENT
Dr. Soto proves there is a similarity and develops an assay to detect misfolded Aβ, a biomarker found in most Alzheimer’s patients.
2014
AMPRION IS FOUNDED
The team expands research to detect other misfolded proteins, including ɑ-synuclein and tau.
2018
CLINICAL LAB ESTABLISHED
The company establishes a state-of-the-art lab run by dedicated scientists and experts, not to mention tireless bots when humans are off the clock.
2019
FDA BREAKTHROUGH DESIGNATION
The US FDA awards Amprion Breakthrough Device Designation for detecting misfolded ɑ-synuclein, an emerging brain disease biomarker.
2022
CAP-ACCREDITED & CLIA-CERTIFIED LAB
Clinical lab is up and running for testing patient samples and SYNTap is made available to clinicians. Service and support functions are activated.
2023
SYNTAP TEST WIDESPREAD ACCESS
Our first biomarker test helps doctors diagnose Parkinson’s disease and Lewy body pathologies by detecting misfolded ɑ-synuclein in CSF.
2024
SAAMPLIFY BIOMARKER PANELS
SYNTap becomes SAAmplify, with Amprion’s flagship ɑ-synuclein SAA heading a new line of comprehensive biomarker panels to aid in diagnosis of neurodegenerative disorders.